Arsenal and Chelsea can both book their Europa League last-32 berths with wins on Thursday night.
The Gunners host Sporting Lisbon in a 10 pm clash at the Emirates Stadium with a chance to cement top spot in Group E – a win will give them a six-point lead over the second-placed Portuguese.
Buoyed by an impressive display in their 1-1 draw against Premier League title hopefuls Liverpool, goalkeeper Bernd Leno believes coach Unai Emery’s team can win top prizes and compete with the best.
The Germans say: “The coach gives us a lot of confidence to play like this.
“I can’t compare it because last year I was not here but I think [Emery] changed some things – of course, the way we play from behind but also to play very aggressive, the defence is getting better, controlled.
“Tactically, it is one step better than at the beginning of the season because it needs time and it also needs time now in the next weeks.
“If we work like this and play like this, we could have a great season.”
Meanwhile, London neighbours Chelsea have one foot in the knockouts.
The Blues travel to BATE Borisov after seeing Alvaro Morata make it five goals in six games in their win over Crystal Palace at the weekend.
Maurizio Sarri’s side is unbeaten since a 2-0 Community Shield loss to Man City in August, and have scored 18 goals over their last six outings.
They top Group L with nine points and will qualify for the last 32 with a win.
Selected Europa League fixtures
Fenerbahce v Anderlecht (5.55 pm)
Rapid Vienna v Villarreal (7.55 pm)
Dynamo Kiev v Rennes (7.55 pm)
Lazio v Marseille (7.55 pm)
Akhisarspor v Sevilla (7.55 pm)
Spartak Moscow v Rangers (7.55 pm)
Bayer Leverkusen v Zurich (10 pm)
Celtic v RB Leipzig (10 pm)
Bordeaux v Zenit (10 pm)
Real Betis v Milan (10 pm)