Wales will be without experienced fullback Leigh Halfpenny for Saturday’s Test against South Africa at the Principality Stadium.
But they have been boosted by the return of wing George North.
Wales assistant coach Rob Howley says Halfpenny will be rested for the clash against the physical Springboks after complaining of feeling light-headed in training over the weekend.
He suffered a concussion after a tackle from Australia’s Samu Kerevi in Wales’ narrow 9-6 victory earlier this month.
And Howley says: “Leigh is out. He did some training on Saturday morning and was feeling a little bit light-headed.
“It’s only common sense.
“From a back three perspective, it gives us an opportunity to look at others.
“Liam Williams has played at fullback, Gareth Anscombe has stepped up there and Hallam Amos has played there.”
Utility back Amos has been added to the squad after last playing for the side against Argentina in June.
Wales head coach Warren Gatland will likely play Anscombe in the fullback position, and select Williams and the returning North on the wing, leaving Dan Biggar to stay in the No.10 jersey.
North returned to training on Tuesday after missing the 74-24 victory over Tonga on Saturday with a bruised leg.