Orlando Pirates and Mamelodi Sundowns both failed to get off to winning starts in their CAF Champions League group-stage campaigns.
Bucs were held to a goalless draw by FC Platinum in Bulawayo, Zimbabwe, in their Group B opener.
In the second half, the Buccaneers pushed hard for an all-important away goal, but it was not to be as Justin Shonga came close for the Sowetans.
Pirates’ Vincent Pule also saw a penalty shout waved away in the dying stages of the game.
Downs, 2016 champions, on Friday evening, were stunned 2-1 by Lobi Stars in Enugu, Nigeria.
Downs dominated the first half and took the lead through Gaston Sirino.
But they made to pay for the wastefulness after the break, as the hosts hit back and killed off fatigued Downs.
Sunday, Kaizer Chiefs were thumped 3-1 in the CAF Confederation Cup group-stage playoff first leg by ZESCO United in Ndola, Zambia, on Sunday.
The hosts took control of after taking a 2-0 lead on their home ground, but Chiefs hit back just before the break through Khama Billiat.
But Kenya hitman Jesse Were restored ZESCO's two-goal cushion before the hour mark.