After the Stormers lost to the Highlanders on Friday, both the Bulls and the Lions lost to overseas opposition while the Sharks smashed the Sunwolves.
In the early match on Saturday, the Bulls came close to a win but the Reds did just enough to edge them 20-14 at the Suncorp Stadium.
Although the visitors raced into a 14-3 lead, it was the Reds who did well to secure the majority of possession after the interval.
Beast Mtawarira then produced a superb Man of the Match performance in his 138th match for the Sharks who comprehensively outplayed the Sunwolves 50-22 in Durban.
It was the Sharks’ first win of the campaign as they scored seven tries to three following a solid 24-3 lead at the interval.
At Ellis Park, the visiting Blues produced a great second-half performance to overturn a 21-10 halftime deficit into a 38-35 upset win over the Lions.
It was a first defeat in four matches for the hosts, while the Blues notched up their first win.
The two sides played a high-octane, attacking game and each team scored five tries, with exciting young wing Aphiwe Dyantyi scoring his fourth try in as many games. The Ioane brothers Rieko (2) and Akira, scored three of the Blues’ tries.
Other weekend results:
Rebels 33 Brumbies 10
Hurricanes 29 Crusaders 19
Jaguares 38 Waratahs 28