Roses winger Jonny May claimed the first-half hattrick as the hosts romped to a 30-8 halftime lead, after Henry Slade adding another and Damian Penaud hit back for France.
England was awarded a penalty try by Nigel Owens when Chris Ashton was tackled without the ball after the break, even though it looked as if Ashton was never in control of the ball.
Pom captain Owen Farrell added a try of his own to his 12 points from the boot after 56 minutes to seal a second straight bonus-point win.
SIX Nations holders Ireland got their campaign back on track with a physical 22-13 victory over Scotland on Saturday.
Scotland’s livewire fullback Stuart Hogg and Ireland’s flyhalf and world player of the year Jonathan Sexton limped off in a close first half, during which the visitors outscored Scotland with two tries to one through Conor Murray and Jacob Stockdale.
Ireland added a third try after the break as replacement flyhalf Joey Carbery hit a gap before releasing winger Keith Earls to score.
Wales notched up a record-equalling 11th straight victory, but only scored two tries through Josh Adams and Owen Watkin, while starting flyhalf Dan Biggar kicked four penalties.
South African-born flanker Brahm Steyn scored the first try of the match, for Italy.