Murray lost out in an epic five-set match against Sam Querrey, who became the first US player to reach the semifinals of Wimbledon since Andy Roddick eight years ago.
Querrey beat Murray 3-6, 6-4, 6-7, 6-1, 6-1 and says: "I’m still in a bit of shock myself. “That last point, I was so happy to get the serve. I’m thrilled right now.
“It feels great - this is a dream come true, to be in the semifinals and to have it at Wimbledon makes it feel more special.
“I’m going to enjoy this win a little bit longer, then have an easy day tomorrow and get ready for the semis."
Querrey will now face seventh-seed Marin Cilic in the semifinal.
This after the dangerous Croatian got the better of Gilles Muller in five sets 3-6, 7-6, 7-5, 5-7 and 6-1 yesterday.
Swiss star Roger Federer, meanwhile, will face Tomas Berdych in the other semi.
Federer made light work of Milos Raonic in their quarterfinal clash, winning 6-4, 6-2 and 7-6, while Berdych's opponent, Novak Djokovic, retired from their match.