After a record-setting romp to the title, Manchester City have their eyes set on a repeat in the new Premier League season.
Liverpool have spent big in their pursuit of the champions while Arsenal face their first season without legendary manager Arsene Wenger.
After a record-setting romp to the Premier League title last season, what does Manchester City do for an encore?
Pep Guardiola's side made history by finishing a record 19 points clear of Manchester United while setting league standards for wins (30), points (100), goals (106) and goal difference (+79).
It's a tough act to follow but Bernardo Silva has an idea with the new season kicking off this weekend.
"If you look over the last few years in the Premier League no one has won two trophies in a row," the midfielder said.
"The last team was United and that was some time ago.
"The other teams will now look at us in a different way and they will want to stop us.
"Our job is to continue in the same way and try to win it again."
Guardiola seeks to become the first manager since Alex Ferguson in 2009 to win back-to-back titles, something he did at previous stops Barcelona and Bayern Munich.
"The players don't have to be worried - I am ready to try it again," he said.
"The fear to lose the games makes me starving and hungry again."
A big change for clubs is the movement of the English transfer deadline to Thursday, putting pressure on teams to get their buying done before the season opens instead of the traditional August 31.
City have just one major addition - Leicester's Riyad Mahrez for 60 million pounds (78 million dollars) - and left the business to the chasing pack.
United have bought a bit but manager Jose Mourinho has complained they need more while Tottenham have stayed quiet, though they did sign manager Mauricio Pochettino and star striker Harry Kane to new deals.
Liverpool, meanwhile, have shelled out more than 170 million pounds on Fabinho, Naby Keita, Xherdan Shaqiri and Alisson as they chase a first trophy under Juergen Klopp.
"We are ambitious, we never said anything different," Klopp, who enters his third full season, said.
"Yes our job is to improve the team every year, to improve the football every year and if you do that then the chances become bigger."
London rivals Chelsea and Arsenal both have new managers.
Maurizio Sarri takes over at Chelsea for the fired Antonio Conte, while Unai Emery replaces the legendary Arsene Wenger at Arsenal.
The Gunners were sixth last season, their worst finish in Wenger's 22 years in charge, and Emery has brought in five new players as the look for a top-four finish and a return to the Champions League.
The three promoted sides all have recent Premier League experience but still may have to work hard to avoid the drop.
Championship winners Wolverhampton Wanderers last played in the top flight in 2012 while Cardiff and Fulham were both relegated two years later.
It was the record eighth promotion for Cardiff boss Neil Warnock, whose side are the bookies' favourites to go straight back down.
"The idea of taking a club up and keeping them up absolutely drives me,' Warnock told the Daily Mail.
"It would be the biggest achievement in my life by a mile.
"If I fail, so what? I'll give it a go and then the club can do what they want.
"I'll give it my best shot."