It will be a historic day, with three South Africans entered for the long jump – including former national record holder Khotso Mokoena and Ruswahl Samaai.
It will be the first time since Rio that Manyonga faces Henderson, who narrowly beat him for the Olympic title last year.
Mokoena will also look to exact revenge after Manyonga demolished his SA record in March before leaping to another continental best of 8.65 metres last month.
The meet is effectively a repeat of the Olympics final with the top six from Rio entered on Saturday.
Manyonga’s coach Neil Cornelius says: “My expectation for Luvo is to win, the distance is not an issue for me. I know there is a lot of talk about him jumping further than nine metres and although I am confident it will happen, he needs to send out a message to his competitors.”