Dragon Quest Builders 2 takes place some time after the events of Dragon Quest II, and revolves around a group called the Children of Hargon. They seek revenge for the defeat of Hargon and Malroth by the descendants of Erdrick, by ensuring that all builders are eliminated and that no one be allowed to create anything.
Players control either a male or female builder, who is captured by this group along with all other builders in the world on a ship.
The player character escapes, washing up on the Isle of Awakening, where they meet a person named Malroth, who has no memory of his past. Malroth aids the player-character in improving their building powers.