Labeeqah suffers from a rare form of cancer known as Myoepithelial carcinoma, and her medicine has to be imported all the way from the United States.
People will be able to bid for the honour to shave the head of a Hopper.
The variety show will feature a number of local acts, including Monox, Mc Manie, Saadicka Davids, Taskeen, Nasneen, Young Gypsies and a live band, among others.
Tickets cost R100 per person.
The show takes place on Saturday at Garlendale High School in Athlone and starts at 7.30pm.