South Africa take on Gambia tomorrow (7pm).
And coach Shakes Mashaba and his manne are desperate for maximum points in that clash and their final qualifier against Mauritania here in South Africa in September.
It is almost a certainty that Bafana, who are second from bottom in Group M having amassed just three points from four games, will not be competing in Gabon next year.
However, Serero is adamant that anything can happen if they put pressure on leaders Cameroon, who face Mauritania this weekend and Gambia three months later.
The 2011 PSL Player of the Year says: “It’s a little bit of a difficult situation, but this is football.
“I have had a good experience of that this season where I lost the championship on the last day of the season.
“We must not give up. If we go out there and put pressure on Cameroon, then there’s a chance that they can lose to Mauritania and maybe even Gambia.”
“It [qualification] is not in our hands, but getting the last six points can change that.”