With both players boasting phenomenal serving power, it would always come down to mental strength and Querrey edged his opponent in that department in a gruelling five-set affair which lasted three hours and seven minutes.
The 31-year-old Anderson can at least console himself with the R2.5m prize money he pocketed as he exited the hallowed grounds of Wimbledon.
While it was hard luck for the South African, World No.1 and home crowd favourite Andy Murray booked his place in tomorrow’s quarterfinal against Querrey.
Murray saw off the challenge of somewhat eccentric Frenchman Benoit Paire in straight sets, winning 7-6, 6-4 and 6-4 in the end.
The win left him full of confidence heading into the rest of the campaign.
After the victory, the Brit said: “I hit the ball well today, maybe there were a couple of sloppy service games in the first set but that’s by far the best I have hit the ball.”