The commission of inquiry into state capture must be accepted by all implicated ministers and other ANC members involved in dealings with the Guptas, she said.
Sisulu said politicians would have to be given the opportunity to explain themselves to the commission of inquiry or other investigating agencies.
She said: “If we find people guilty of corruption, we must find a way to expel them.
“My message to all of them is that it will be a good thing. It will clear the air. We, as the ANC, are suffering huge damage – a huge confidence deficit. The quicker this is dealt with, the better. The public out there wants to see this matter resolved.
“For us as the ANC, these accusations are too dire. They are like a noose around our necks.
“We are a decisive organisation. I don’t know why we are dilly-dallying.”